Inflammation is one of the many ways the immune system protects the body. Sometimes, however, it can harm your health. Acute inflammation occurs in reaction to injuries, bacteria, and viruses, while chronic inflammation is due to autoimmune diseases such as arthritis and is not associated with normal healing processes. Learn what role inflammation plays in Parkinson’s to help yourself or a loved one with the disease manage symptoms.

What to Know About Parkinson’s & Inflammation

Brain Inflammation & Disease Progression

Inflammation is a cause as well as a result of Parkinson’s disease. When an individual has Parkinson’s, the body produces the alpha-synuclein protein at an abnormal rate, resulting in protein clumps known as Lewy bodies. These clumps appear in many neurological diseases in addition to Parkinson’s, including dementia with Lewy bodies (DLB). As more of these entities appear in the brain, movement issues develop. Lewy body accumulation also causes inflammation as the body attempts to protect itself, resulting in further disease progression.

Additionally, research indicates inflammation contributes to brain cell death. Symptoms such as fatigue, anxiety, depression, and poor cognition are all considered inflammatory markers in Parkinson’s patients.

Research & Controlling Inflammatory Responses

Researchers are currently looking for ways to control the body’s inflammatory reaction to alpha-synuclein protein buildup with clinical trials for certain drugs. Inosine monophosphate dehydrogenase (IMDH) inhibitors are among the immunosuppressant drugs currently being explored for this reason.

Dietary supplements may also help control brain inflammation in Parkinson’s patients according to recent research, such as vitamin E and omega-3 fatty acids. Vitamin E protects brain cells against oxidative damage, while omega-3s promote healthy cell growth and muscle activity. The body doesn’t produce these fatty acids, but requires them to maintain brain as well as blood and skin health. They’re found in fish, avocados, nuts, and flax seeds.
 

In addition to controlling brain inflammation with a healthy diet and the right medications, there are many other steps you can take to manage Parkinson’s symptoms. For more advice on available resources, turn to the volunteers at Connecticut Advocates for Parkinson’s. They provide support services for Parkinson’s patients and their loved ones in and around Hartford County, including clinical trial transportation, exercise classes, and patient group collaborations. Call (860) 266-6040 today to learn about volunteer opportunities or view the online calendar for the latest events. Like the Facebook page to never miss an update.